Partnering opportunity

Serpin inhibitors for the treatment of prion and prion like diseases - License agreements and joint venture opportunity

Summary

A research group based in Italy has developed a new class of small molecules acting as SERPINA3 inhibitors, which are able to reduce prion protein (PrPSc) accumulation in prion-infected cell lines, thereby representing a new therapeutic treatment against prion and prion-like diseases. They are looking for licence agreements and joint venture agreements with pharma companies and/or financial agreements with investors.

Partner sought

Pharma Companies/Investors interested in acquiring and co-developing the technology.

Description

To date, despite numerous active efforts, there are no drugs available for the cure of the neurodegenerative diseases collectively referred as prion and prion-like disorders. Symptomatic treatment is the only available option, including the administration to patients of antipsychotics, such as quetiapine and clonazepam, to treat myoclonus, and of selective serotonin re-uptake inhibitors (SSRIs) to treat depression. Indeed, through this invention, the technology transfer office of a research center based in the North of Italy and internationally renowned, is presenting a new class of small molecules. These small molecules are acting as SERPINA3 inhibitors, which are able to reduce PrPSc accumulation in prion-infected cell lines, thereby representing a new therapeutic treatment against prion and prion-like diseases. The development of specific inhibitors of SERPINA3 with an activity in the nanomolar range is expected. The characterization of structural models of the binding of the small molecules with the protein should allow the identification of novel inhibitors with improved potency. The research center is looking for licence agreements or joint ventures with industry (pharma companies) or financial agreements with investors interested in developing new drugs.

Advantages and innovations

So far there are no effective therapies for prion diseases. The proposed technology aims at developing novel molecules with improved efficacy on these diseases.

Development stage

Under development/lab tested

Intellectual Property Rights (IPR)

Patent(s) applied for but not yet granted


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