Dual phase spray technology to develop pharmaceutical products delivering drag for tissue regeneration and to produce biocompatible polymeric 3D products
A mechatronic Italian SME implemented and patented a technology based on phase inversion and developed a “spray machine” tested to produce biocompatible patches for tissues regeneration and heart valves having polymeric base. Company search pharmaceutical industries interested to develop new medical products using spray technology, research centres to study biomaterials and health structures for clinical trials. Technical and research cooperation agreements are proposed.
Medium and big Pharmaceutical and dentistry devices companies to collaborate in new products prototype develop and produce and commercialize the news products resulting from the project. The type of partnership considered is technical agreement. University Laboratories and Research Centre to study and develop the biomaterials in collaboration also with the Italian Centre yet involved by applicant company. The partnership considered is research cooperation agreement. Hospitals, Health and Dentistry structures to implement the clinical trials. Suggested partnership is research cooperation agreement.
The applicant is an Engineering Italian company founded in 1991 as University spin off. Company is skilled to design and develop mechatronics products and robotic systems for industrial customers and as partner on R&D EU and National projects. The company is part of a US medium-sized Group producing and selling industrial and medical equipments on the global markets. Innovative solution The company, in collaboration with an Italian Research Centre skilled in biomaterials, has developed and patented a technology, based on phase inversion, and a “spray machine” advanced prototype that allows to manufacture biocompatible pharmaceutical products for regeneration of tissues (eg patches for the treatment of ulcerative sores). A subsequent version of the spray machine prototype (also patented) has been set up with a robotic arm, which allows to manufacture three-dimensional medical prostheses (for example heart valves) with a polymeric base with modular physical and mechanical properties depending on the end use. The spray machine have two spray-guns that spray the polymeric solution and a non-solvent material focusing the jets in a precise point of the spindle (if a bi-dimensional patch is to be made) or on a mould model (if a shape is to be made three-dimensional such as a heart valve). Markets target: medical applications for therapy of the ulcerative diabetic sores and application for dentistry. Collaboration offered Applicant company can study, implement and industrialize the customized manufacturing solutions for new medical products for tissue regeneration defined by the health and industrial partners The company can also involve in the project the Italian biomaterial R&D Centre Research Centre that has already collaborated to the spray technology develop and testing. This R&D Centre is able to define, implement and test the new biomaterial requirements. The company offers research cooperation agreements to University Laboratories and Research Centre to study and develop the biomaterials. Medium and big Pharmaceutical and dentistry devices companies are sought to collaborate with technical agreements in the new products prototyping, developing, production and commercialization. The company seeks also for Hospitals Health and Dentistry structures to implement the clinical trials with research cooperation agreements.
Advantages and innovations
The spray machine uses the phase inversion technology to create three-dimensional polymer-based constructs, with physical and mechanical properties that can be modulated according to the end use. This system allows to spray at the same time a polymeric solution and a non-solvent focusing the jets in a precise point. Phase inversion technique allows to generate complex three-dimensional structures starting from polymeric solutions thermodynamically unstable and sprayed through two spray-guns. The three-dimensional structure generated, similar to a "non-woven fabric", can assume different porosities, properties and morphological characteristics depending on the regulation of the manufacturing parameters. The nanostructured patch developed by spray technology has been tested as device delivering drug of the growth factors contained in the platelet concentrate. Therapeutic efficacy has been verified “in vivo” on chronic sores of diabetic mouses.
Intellectual Property Rights (IPR)
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